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What Is The Best Supplements for Leaky Gut?

Supplements For Leaky Gut

[vc_row][vc_column][vc_column_text]Leaky Gut Syndrome is a condition where undigested proteins like gluten, microbes and even toxins can pass into the bloodstream.

Also known as intestinal permeability, Leaky Gut Syndrome can increase your chances of several chronic conditions if left untreated.

Fortunately, there are plenty of ways to improve your gut health and tackle the symptoms of a leaky gut, from supplements for leaky gut to changing your diet.

Everyone’s guts are semi-permeable, as the lining of our intestines transfers water and nutrients from our food into our bloodstream, though some people’s guts let in larger, potentially toxic molecules. In a healthy gut, your intestines are resistant to harmful substances and only allow useful nutrients to pass into your bloodstream, but this barrier can break down over time, requiring medical treatment or supplements for leaky gut syndrome.

These ‘leaks’ may be letting toxins into your bloodstream, causing widespread inflammation, which can trigger an immune response if not treated with the best supplements for leaky gut or medical treatment. However, there is no easy way to cure Leaky Gut Syndrome, as it is often linked to chronic gastrointestinal issues, though there are many ways to manage your symptoms.

How do you heal a leaky gut fast?

Leaky gut syndrome is when the tight junctions between cells lining your small intestine loosen, allowing fragments of bacteria and undigested food to enter your bloodstream. These leaks are often due to the protective mucous layer in your gut breaking down due to inflammation, which is often caused by lifestyle factors, so even the best supplements for leaky gut may not help as much as meaningful lifestyle changes.

Adopting a ‘leaky gut diet’ of healthy, whole foods that is low in ultra-processed foods and includes supplements for leaky gut syndrome is one of the most effective things you can do to improve your leaky gut. However, the time it takes to heal a leaky gut will be different for everyone, and while many gut conditions can improve in a matter of weeks, most leaky gut treatments focus on long-term solutions rather than quick fixes.[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text el_class=”bullets-single-line”]

What are the 3 signs of a leaky gut?

leaky gut

Leaky Gut Syndrome can cause a wide variety of symptoms – both in your digestive system and all over your body – though the three most common signs of a leaky gut are:



  • Gas and bloating
  • Diarrhoea or constipation
  • Heartburn or reflux

However, because leaky gut syndrome allows undigested food and bacterial fragments to enter your bloodstream, it can cause inflammatory symptoms all over the body, including:

  • Brain fog
  • Joint pain
  • Fatigue
  • Food sensitivities/allergies
  • Food cravings, especially for carbs
  • Skin irritation like acne or rashes
  • Nutritional deficiencies like anaemia

Studies show that people with chronic gastrointestinal diseases like IBS, colitis and Crohn’s disease are more likely to have these symptoms, but they may manifest independently. Most of these symptoms are minor and can be treated with gut health supplements and lifestyle changes, but you should see a doctor if they are frequent or chronic.[/vc_column_text][/vc_column][/vc_row][vc_row el_class=”icon-box-styles icon-yellow-unaligned-br-style-1 icon-yellow-unaligned-br-style-2″][vc_column][vc_column_text]

What causes a leaky gut?

While the main cause of the leaky gut syndrome is inflammation, there are many contributing factors, such as your diet and lifestyle. Common food components that may contribute to a leaky gut include sugar, dairy, gluten, and alcohol, so you should limit the amounts of these substances in your diet if you have a sensitive stomach or leaky gut.[/vc_column_text][vc_column_text el_class=”blue-box-text”]Other factors that can cause a leaky gut include:

  • Chronic Stress: Prolonged stress can weaken your immune system and worsen inflammation and leaky gut syndrome symptoms. While supplements for leaky gut syndrome can help with some of these symptoms, you need to lower your stress levels to improve your overall health in the long term.
  • Dysbiosis: This condition is effectively an imbalance of beneficial and harmful bacteria and most commonly occurs in the gut. Dysbiosis is associated with chronic fatigue, IBS and colitis, so sufferers of these diseases may benefit from probiotic supplements.

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What Naturally Helps Leaky Gut?

A leaky gut can affect all aspects of your health, from the nutrients you absorb to the normal functioning of your brain, so gut health is central to your health. Fortunately, there are plenty of ways to naturally improve your gut health without having to shell out for expensive medical treatment or the best supplements for leaky gut, such as:

[/vc_column_text][icon_box icon_position=”left” border=”0″ title=”Eating anti-inflammatory foods:”]Because inflammation is a major factor in leaky gut syndrome and most chronic gastrointestinal diseases, eating a diet rich in anti-inflammatory foods can help reverse this damage. Several studies show that improving your diet can reverse intestine permeability, so we recommend a diet rich in whole foods, especially fresh fruit and vegetables, for the best results.[/icon_box][icon_box border=”0″ title=”Supporting your body’s stress response:”]The next biggest factor for leaky gut syndrome is stress, as there is a well-documented link between your gut health and chances of developing stress-related conditions like anxiety and depression. Whether stress causes gastrointestinal issues or vice versa, supporting your body’s ability to handle stress is just as important as supplements for leaky gut syndrome, so make sure to get plenty of water, sleep and time to relax.[/icon_box][icon_box icon_position=”left” border=”0″ title=”Exercising Daily:”]Regular exercise has many health benefits – from releasing feel-good chemicals to improving heart health – and may help cure leaky gut syndrome. Studies show that regular cardiovascular exercise can help promote a healthy gut microbiome and support stable microflora diversity, so regular exercise should be a part of any long-term leaky gut treatment.[/icon_box][/vc_column][/vc_row][vc_row][vc_column][vc_row_inner el_class=”icon-box-styles icon-box-half-br-1 icon-box-half-br-2″][vc_column_inner][vc_column_text]

What supplements help repair the gut?

Because leaky gut syndrome can be caused by various factors (from stress-related inflammation to an unhealthy diet or alcoholism), many supplements for leaky gut syndrome might help you. Here are our top three recommendations for the best supplements for leaky gut that will help balance your gut bacteria, reduce inflammation and restore your gut lining:[/vc_column_text][icon_box border=”0″ title=”1. Probiotics and prebiotics” image=”3452″]Probiotics are widely used in managing and treating gastrointestinal diseases – including leaky gut syndrome – as they help improve your gut microbiome, benefiting your overall health. Additionally, probiotics perform multiple functions simultaneously, reducing leaky gut symptoms whilst tackling the root causes like inflammation, making them some of the best gut health supplements.
RELATED: Learn more about the benefits of probiotic supplements here.[/icon_box][icon_box icon_position=”left” border=”0″ title=”2. L-Glutamine” image=”3453″]Glutamine is an important amino acid naturally produced in your gut and is best known for helping repair the intestinal lining, making it an obvious suggestion for gut health supplements. Supplementing with L-Glutamine helps to improve gut barrier function, speed the repair of the intestinal lining and reduce inflammation, making it highly recommended for treating leaky gut syndrome.[/icon_box][icon_box border=”0″ title=”3. Vitamin D” image=”3454″]Vitamin D is a natural antioxidant that helps reduce inflammation and maintain immune system balance in your gut, reducing intestinal permeability and symptoms of gastrointestinal diseases like IBS. Furthermore, vitamin D has a wide variety of general health benefits, such as improved bone health, making it great in leaky gut treatment supplements and beneficial for almost everyone.[/icon_box][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_column_text]

Other Supplements for Leaky Gut Syndrome

In addition to these three, there are a variety of other supplements that can help treat leaky gut syndrome, reduce inflammation and support the healing of your gut lining, including:


Zinc is an essential mineral with well-known immune-boosting benefits, and a 2001 study found that zinc supplements helped strengthen the gut lining of people with Crohn’s disease.

Collagen peptides

Collagen peptides are a more digestible and bioavailable form of collagen that may prevent the breakdown of the intestinal lining and tackle gut inflammation, making them desirable in gut healing supplements.

Fiber and butyrate

Dietary fiber helps support a healthy gut microbiome and helps your gut flora produce butyrate – an amino acid that supports mucus production and improves your gut lining – though you can enjoy the same benefits by supplementing with butyrate.

Deglycyrrhizinated licorice (DGL)

Licorice root is a natural laxative with nearly 75 bioactive compounds, including glycyrrhizin (GL), which causes adverse effects in humans. One of the best ways to enjoy its benefits – like reducing gut inflammation – is with glycyrrhizinated licorice (DGL) gut cleanse supplements.


Curcumin – the main active compound in turmeric – has anti-inflammatory effects that may help reduce intestinal permeability, though it has not yet been tested in clinical leaky gut treatments.


Berberine is a bioactive plant-based alkaloid with antioxidant and anti-inflammatory properties that has historically been used to treat inflammatory bowel diseases, though there is limited evidence to support claims it is the best vitamin for gut health.[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text]

How do I get rid of inflammation in my gut?

You may be accustomed to managing the unpleasant symptoms of common gastrointestinal diseases, but much of this comes down to one underlying factor – inflammation. Fortunately, there’s lots you can do to tackle your gut inflammation that doesn’t involve shelling out for gut health supplements, such as:

Eating an anti-inflammatory diet

Avoid inflammatory food and drink like refined carbs, artificial sweeteners and highly processed foods, opting instead for anti-inflammatory foods like:

  • Colourful berries like cherries and grapes
  • Broccoli, cauliflower, kale, and cabbage
  • Turmeric, cinnamon and fenugreek
  • Olive and coconut oil

Trying an elimination diet

If you suspect certain foods trigger inflammation in your gut, try eliminating foods that may be linked to your gut issues for 2-3 weeks before turning to gut cleanse supplements. Some foods that commonly trigger inflammation include:

  • Soy
  • Dairy
  • Citrus Fruits
  • Nightshade Vegetables*
  • Gluten

*Nightshade vegetables are a broad group of plants from the solanum and capsicum families, including tomatoes, potatoes, bell peppers, chilli peppers, eggplants, tomatillos and blueberries.

Lowering your stress levels

Stress, especially frequent or chronic stress, is linked to inflammation, so try to reduce your stress levels with relaxing activities like meditation, yoga, or a walk around the block to reduce inflammation alongside the best supplements for leaky gut.

Taking Probiotics

Probiotics help promote a healthy gut microbiome, which improves your body’s response to inflammation whether you get your probiotics from foods (like yogurt, kimchi or kombucha) or supplements.

Ensure you’re getting enough nutrients

Your body needs plenty of nutrients to fight inflammation, so make sure you’re getting a balanced diet high in anti-inflammatory nutrients like vitamin D, omega 3s and magnesium or take supplements for leaky gut to boost your intake.

Can leaky gut be cured permanently?

Can leaky gut be cured permanently

Unfortunately, no known treatment or gut health supplements can permanently cure leaky gut syndrome or the gastrointestinal diseases that cause it. Mainstream medicine generally recognizes Leaky Gut Syndrome (LGS) – AKA increased intestinal permeability – as a symptom of other diseases, not a condition of its own, so research is mainly focused on gastrointestinal diseases, not LGS itself.

Subsequently, most knowledge of leaky gut syndrome stems from research on other conditions, like IBS, Crohn’s disease and colitis, which cannot be permanently cured as far as we know. Because most gastrointestinal diseases are caused by inflammation or genetic factors, the closest thing to a permanent ‘cure’ lies not in supplements for leaky gut, but in being lucky enough not to have a genetic predisposition to LGS and making healthy lifestyle changes like:

  • Eating a healthy diet
  • Taking probiotics
  • Limiting your intake of alcohol and NSAIDs*
  • Reducing stress
  • Quitting smoking

*Nonsteroidal Anti-Inflammatory Drugs (or NSAIDs) such as aspirin and ibuprofen can increase your risk of gastrointestinal ulcers and leaky gut syndrome.[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text el_class=”bullets-single-line”]

Which probiotics are best for leaky gut?

Which probiotics are best for leaky gut

Probiotics are strains of beneficial bacteria that are incredibly beneficial gut health supplements, as they help improve the balance of organisms in your gut and reduce inflammation. While probiotics are clinically proven to reduce intestinal permeability and promote intestinal repair, not all of them are created equal, so what are the best probiotics to use in leaky gut treatment?

While probiotics may be some of the best supplements for leaky gut, their effects can vary significantly. Most probiotics come from two main genera – Bifidobacteria and Lactobacillus:

Bifidobacteria – commonly used in foods and supplements, bifidobacteria are thought to:

Lactobacillus – these bacteria produce lactase (the enzyme that breaks down lactose AKA milk sugar) and lactic acid, which helps control the bad bacteria population, among other things. Lactobacillus bacteria are naturally found in the mouth, small intestine and vagina and may provide various health benefits when taken as a supplement, such as:

  • Reducing cholesterol
  • Preventing diarrhoea
  • Improving IBS symptoms
  • Preventing vaginal infections
  • Promoting weight loss

However, using probiotics to treat leaky gut syndrome is based on restoring balance to your gut microbiome, so you should take a mix of different probiotics for the best results. Additionally, you should avoid gut cleanse supplements, as they often cause an imbalance in your gut microbiome, the opposite of what you want to do with probiotic supplements.[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text]


Leaky gut syndrome – or increased intestinal permeability – is often misunderstood, not least because it is medically recognized as a symptom of other gastrointestinal diseases. Fortunately, it can be treated with simple lifestyle changes and supplements for leaky gut, though there is no quick fix or single supplement for leaky gut syndrome or the gastrointestinal diseases that can cause it.

If you suffer from Leaky Gut Syndrome symptoms (especially if these symptoms persist over long periods), you may have an underlying gastrointestinal disease. Many gastrointestinal diseases are best treated early, so consider seeing a doctor about your symptoms rather than relying on leaky gut treatment supplements which are not clinically proven.[/vc_column_text][/vc_column][/vc_row]

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Written and Researched by

SupplementsYouCanTrust is made up of passionate health writers dedicated to providing reliable information on supplements and vitamins. With backgrounds in nutrition, medicine, and research, our team brings a diverse range of perspectives and expertise to the table.
Dr Wasim Khan

Medically Reviewed by

Dr. Wasim Khan’s areas of expertise lie in understanding the role of dietary supplements and vitamins in healthcare. His in-depth knowledge allows him to provide comprehensive advice and help you make informed decisions about your nutritional intake and supplement usage.

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