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How Long for NMN To Start Working?

How Long for NMN To Start Working

NMN (Nicotinamide mononucleotide) is one of the best molecules found naturally in the human body.

Studies show that it plays an important role in weight maintenance, energy levels, vitality, improved insulin sensitivity, longevity, eyesight and exercise performance.

Given all this, it’s only natural to ask yourself how long for NMN to start working?

You’ll see benefits start at the two-week mark and feel most of its effects about a month into daily supplementation.

However, it’s not as simple as this and things can’t just be summed up in one sentence. So, keep reading as I’ll explain in detail how NMN works in your body from day on to six months of supplementation.

What is NMN?

What is NMN

In humans, NMN is a key molecule consisting of nicotinamide, ribose, nicotinamide riboside and niacin.

While the body produces this molecule on its own, NMN deficiency is common, especially amongst older generations.

This can lead to various complications, such as low energy levels, rapid aging, neurodegenerative diseases and is even linked to Parkinson and Alzheimers!

Luckily, NMN supplementation is readily available and can help offset the many side effects related to its deficiency.

Let me give a quick overview of how it works.

How Does NMN Work?

NMN is turned into NADH (nicotinamide adenine dinucleotide) in the body, which is a coenzyme responsible for metabolic health and oxidation of cells.

It’s also very important for the formation of proteins and keeping your muscle mass intact, which is one of the main reasons why NMN is so good at preventing osteoporosis.

It also has other extracellular benefits that are still being investigated by scientists.

Some researchers have even gone as far as to call it a “novel” neurotransmitter.

How Long for NMN To Start Working?

How Long for NMN To Work

I will show you exactly what happens, from day one to six months into daily NMN supplementation, so you know exactly what you can expect.

For the first two weeks, the body is readily storing the NMN you’re consuming and you won’t feel much of the positive effects. In this instance, NMN is similar to antidepressants, it takes a while to build-up in the body.

Around the two week mark, you’ll start feeling the first effects; energy levels will be heightened and you’ll most likely have an easier time managing your weight.

One month in is when NMN really starts to shine, that’s when you can expect better eyesight, metabolic improvements and enhanced exercise performance.

Also important to note is that your NADH levels will have increased by up to 50% at this point. This is exactly the effect we’re looking for, as NADH leads to the benefits described in the section above.

Just two more weeks and NMN will lead to better insulin sensitivity, which means you won’t have to worry about some of the debilitating diseases such as diabetes.

Not just that, it also means that your blood sugar levels will drop and some people also experience a drop in triglycerides and bad cholesterol.

This all leads to better blood flow in your cardiovascular system, keeping your heart healthy and can also prevent heart disease.

After three months, you’ll feel like a new and improved human being, your physical attributes will be enhanced and you’ll be much faster in performing your daily chores.

I have even heard of cases where people who usually led sedentary lifestyles start running or even going to the gym, as a result of the increased energy levels.

Last but not least, the most important benefit of NMN are its anti-aging effects. You won’t automatically look 20 years younger, but you’ll feel like you’ve dropped 20 years from your chronological age!

What is The Best NMN Dosage?

The best way to supplement NMN is via pills, it’s recommended to start off with a lower dosage and slowly increase it during the course of two weeks.

As already mentioned, NMN takes a while to build-up in the body, so there’s no reason to start blasting it full on from the get-go.

250mgs a day is a good start and you’ll want to increase that dosage to 500mgs per day within a fortnight.

Most pills come in either 250mgs or 500mgs dosages, you won’t have to worry about having to split them.

It’s also very important to take them on an empty stomach and from my experience, they work best when taken early in the morning, as soon as you wake up.

That’s because your body is most active during the day, allowing for better NMN absorption and increased bioavailability.

Don’t forget to wait at least an hour before eating anything after taking NMN, as food can inhibit absorption rates.

For people of a certain age, which are at higher risk of the many side effects of NMN deficiency, taking up to 1000mgs a day is recommended. As always, you’ll want to slowly increase the dosage so as to not shock your body.

What Should I Look Out For In NMN Supplements?

It’s important that your NMN is at least 99% pure or more and that it is stored in a proper way.

NMN degradation is a real thing, so you’ll want to make sure to keep it in a cool and dark place, where it’s not too hot, but also not as cold as to be freezing.

Another thing of importance is testing. Some NMN brands simply source their product from who knows where and don’t perform adequate testing to ensure their product is pure.

That’s why you’ll have to look for companies that perform tests at independent, third-party laboratories, as to mitigate any possible conflicts of interest.

Also look out whether your NMN is filled with GMOs or any other fillers, these are not necessary and may lead to unwanted side effects.

Frequently Asked Questions (FAQ)

Are there any side effects to NMN?

NMN is produced naturally by the body, so you shouldn’t experience any side effects. Rarely, some mild adverse effects, such as diarrhea, gas and abdominal pain may crop up.

Is it safe to take NMN on a daily basis?

Not only is it safe, but it’s also recommended to keep your NMN levels in the body at an optimal level.

What are some of the food sources of NMN?

The best food sources of NMN are fruits and vegetables, such as oranges, avocado, broccoli and potatoes.

Does NMN make you look younger?

It might. Some people do report looking younger after half a year of daily supplementation, while others only feel younger. It’s a crapshoot.

How do I know if my NMN supplement is working?

Many people give up on NMN too early. You need at least two weeks to start feeling its effects in the body, but once it starts working, you’ll know it’s showtime!

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Written and Researched by

SupplementsYouCanTrust is made up of passionate health writers dedicated to providing reliable information on supplements and vitamins. With backgrounds in nutrition, medicine, and research, our team brings a diverse range of perspectives and expertise to the table.
Dr Wasim Khan

Medically Reviewed by

Dr. Wasim Khan’s areas of expertise lie in understanding the role of dietary supplements and vitamins in healthcare. His in-depth knowledge allows him to provide comprehensive advice and help you make informed decisions about your nutritional intake and supplement usage.